0 Datasets
0 Files
Get instant academic access to this publication’s datasets.
Yes. After verification, you can browse and download datasets at no cost. Some premium assets may require author approval.
Files are stored on encrypted storage. Access is restricted to verified users and all downloads are logged.
Yes, message the author after sign-up to request supplementary files or replication code.
Join 50,000+ researchers worldwide. Get instant access to peer-reviewed datasets, advanced analytics, and global collaboration tools.
✓ Immediate verification • ✓ Free institutional access • ✓ Global collaborationJoin our academic network to download verified datasets and collaborate with researchers worldwide.
Get Free AccessLevels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Global BPgen Consrotium, Ulla Sovio, Alan R. Shuldiner, George Dedoussis, Lori L. Bonnycastle, Serge Hercberg, Yii‐Der Ida Chen, Sophie Visvikis‐Siest, Meena Kumari, Pierre Meneton, Yavuz Ariyürek, Josephine M. Egan, Yoav Ben‐Shlomo, Nita G. Forouhi, J. Graessler, Igor Rudan, Nancy L. Pedersen, Cecilia M. Lindgren, Peter S. Chines, Heather M. Stringham, Christa Meisinger, Cristian Pattaro, Nicole Vogelzangs, DIAGRAM Consortium, Thomas Illig, Claudia Langenberg, Björn Zethelius, Avan Aihie Sayer, Markku Laakso, Man Li, Robert Clarke, Bo Isomaa, Jarred B. McAteer, Alex S. F. Doney, Oluf Pedersen, Torben Jørgensen, Yvonne Böttcher, Shah Ebrahim, Peter E. H. Schwarz, Cécile Lecœur, Bruce M. Psaty, Peter Shrader, Beatrice Knight, John Beilby, Christian Gieger, Samuli Ripatti, Jing Zhao, Christian Herder, Mario A. Morken, Y. Antero Kesäniemi, Marco Orrù, Braxton D. Mitchell, Barbara Thorand, Valeriya Lyssenko, Praveen Sethupathy, David Meyre, Torben Hansen, Nigel W. Rayner, Naomi Hammond, Nicholas J. Timpson, Serena Sanna, Eric J. Brunner, Guangju Zhai, Jacqueline C.M. Witteman, Denis Rybin, Marilyn C. Cornelis, Katja K.H. Aben, Gonneke Willemson, Marika Kaakinen, John R. B. Perry, Diana Zélénika, G. Bragi Walters, Simon Heath, Ben A. Oostra, Veikko Salomaa, Kim L Ward, Ko Willems van Dijk, Gordon H. Williams, Fredrik Karpe, Peter Wagner, Reedik Mägi, Antje Fischer‐Rosinsky, Göran Hallmans, Taina K. Lajunen, Lu Qi, Paul Navarro, Harald Grallert, Peter P. Pramstaller, Jaakko Kaprio, Nicholas L. Smith, Caroline Hayward, Annelli Sandbæk, Thomas Sparsø, Christian Dina, Giuseppe Paolisso, Alan F. Wright, Massimo Mangino, Peter Henneman, George Davey Smith (2019). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. , DOI: https://doi.org/10.17615/qp7m-ew12.
Datasets shared by verified academics with rich metadata and previews.
Authors choose access levels; downloads are logged for transparency.
Students and faculty get instant access after verification.
Type
Article
Year
2019
Authors
99
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.17615/qp7m-ew12
Access datasets from 50,000+ researchers worldwide with institutional verification.
Get Free Access
.webp){kind=avatar}
