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Get Free AccessMyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
Karl S. Lang, Alexander A. Navarini, Mike Recher, Philipp A. Lang, Mathias Heikenwälder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Akira Shizuo, Kenya Honda, Hans Hengartner, Rolf M. Zinkernagel (2007). MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. European Journal of Immunology, 37(9), pp. 2434-2440, DOI: 10.1002/eji.200737310.
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Type
Article
Year
2007
Authors
12
Datasets
0
Total Files
0
Language
English
Journal
European Journal of Immunology
DOI
10.1002/eji.200737310
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