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Get Free AccessWhile more samples are needed to reach genome-wide levels of significance, the results presented confirm PPD as a polygenic and heritable phenotype. There is also evidence that despite a high correlation with MDD, PPD may have unique genetic components. Cell enrichment results suggest GABAergic neurons, which converge on a common mechanism with the only medication approved by the U.S. Food and Drug Administration for PPD (brexanolone).
Jerry Guintivano, Enda M. Byrne, Jacqueline Kiewa, Shuyang Yao, Anna E. Bauer, Karolina A. Åberg, Mark J. Adams, Archie Campbell, Megan L. Campbell, Karmel W. Choi, Elizabeth C. Corfield, Alexandra Havdahl, Donald Hucks, Nastassja Koen, Yi Lu, Merete Lund Mægbæk, Jimmy Mullaert, Roseann E. Peterson, Laura M. Raffield, Hannah Sallis, Julia Sealock, Alicia Walker, Hunna J. Watson, Ying Xiong, Jessica Yang, Richard Anney, Katherine Gordon‐Smith, Leon Hubbard, Lisa Jones, Raluca Mihăescu, Mette Nyegaard, Antonio F. Pardiñas, Amy Perry, Nazmus Saquib, Aladdin H. Shadyab, Alexander Viktorin, Ole A. Andreassen, Tim B. Bigdeli, Lea K. Davis, Cindy‐Lee Dennis, Arianna Di Florio, Caroline Dubertret, Yen‐Chen Anne Feng, Benício N. Frey, Sophie Grigoriadis, Emilie Gloaguen, Ian Jones, James L. Kennedy, Holly Krohn, Theodora Kunovac Kallak, Yun Li, Nicholas G. Martin, Andrew M. McIntosh, Jeannette Milgrom, Trine Munk‐Olsen, Tim F. Oberlander, Catherine M. Olsen, Nicolás Ramoz, Ted Reichborn‐Kjennerud, Emma Robertson Blackmore, David Rubinow, Alkistis Skalkidou, Jordan W. Smoller, Dan Joseph Stein, Zachary N. Stowe, Valerie H. Taylor, Sarah Tebeka, Martin Tesli, Ryan J. Van Lieshout, Edwin J. C. G. van den Oord, Simone N. Vigod, Thomas Werge, Lars T. Westlye, David C. Whiteman, Heather J. Zar, Naomi R. Wray, Samantha Meltzer‐Brody, Patrick Sullivan (2023). Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression. , 180(12), DOI: https://doi.org/10.1176/appi.ajp.20230053.
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Type
Article
Year
2023
Authors
78
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1176/appi.ajp.20230053
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