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Get Free AccessInterleukin-18 (IL-18) is a potent cytokine with many different proinflammatory activities. To study the role of IL-18 in the pathogenesis of Pseudomonas pneumonia, IL-18-deficient (IL-18(-/-)) and wild-type mice were intranasally inoculated with Pseudomonas aeruginosa. IL-18 deficiency was associated with reduced outgrowth of Pseudomonas in the lungs and diminished dissemination of the infection. In addition, pulmonary inflammation (histopathology) and levels of tumor necrosis factor alpha, IL-6, and macrophage inflammatory protein-2 in lungs and plasma were lower in IL-18(-/-) mice. Consistent with results obtained for IL-18(-/-) mice, treatment of wild-type mice with a neutralizing IL-18 binding protein-immunoglobulin G Fc fusion construct also attenuated outgrowth of Pseudomonas compared with that for mice treated with a control protein. These results demonstrate that the presence of endogenous IL-18 activity facilitates inflammatory responses in the lung during Pseudomonas pneumonia, concurrently impairing bacterial clearance.
Marc J. Schultz, Sylvia Knapp, Sandrine Florquin, Jennie M. Pater, Kiyoshi Takeda, Akira Shizuo, Tom van der Poll (2003). Interleukin-18 Impairs the Pulmonary Host Response to<i>Pseudomonas aeruginosa</i>. Infection and Immunity, 71(4), pp. 1630-1634, DOI: 10.1128/iai.71.4.1630-1634.2003.
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Type
Article
Year
2003
Authors
7
Datasets
0
Total Files
0
Language
English
Journal
Infection and Immunity
DOI
10.1128/iai.71.4.1630-1634.2003
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