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Get Free AccessStage III metastatic melanomas require adequate adjuvant immunotherapy to prevent relapses. Prognostic factors are awaited to optimize the clinical management of these patients. The magnitude of metastatic lymph node invasion and the BRAF(V600) activating mutation have clinical significance. Based on a comprehensive immunophenotyping of 252 parameters per patient in paired blood and metastatic lymph nodes performed in 39 metastatic melanomas, we found that blood markers were as contributive as tumor-infiltrated lymphocyte immunotypes, and parameters associated with lymphocyte exhaustion/suppression showed higher clinical significance than those related to activation or lineage. High frequencies of CD45RA(+)CD4(+) and CD3(-)CD56(-) tumor-infiltrated lymphocytes appear to be independent prognostic factors of short progression-free survival. High NKG2D expression on CD8(+)tumor-infiltrated lymphocytes, low level of regulatory T-cell tumor-infiltrated lymphocytes, and low PD-L1 expression on circulating T cells were retained in the multivariate Cox analysis model to predict prolonged overall survival. Prospective studies are needed to determine whether such immunological markers may guide adjuvant therapies in stage III metastatic melanomas.
Nicolas Jacquelot, María Paula Roberti, David Enot, Sylvie Rusakiewicz, Michaëla Semeraro, Sarah Jégou, Camila Flores, Lieping Chen, Byoung S. Kwon, Christophe Borg, Benjamin Weide, F. Aubin, Stéphane Dalle, Holbrook E. Kohrt, Maha Ayyoub, Guido Guido Kroemer, Aurélien Marabelle, Andréa Cavalcanti, Alexander Eggermont, Laurence Zitvogel (2016). Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis. , 136(5), DOI: https://doi.org/10.1016/j.jid.2015.12.042.
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Type
Article
Year
2016
Authors
20
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.jid.2015.12.042
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