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Get Free AccessHER3-DXd and T-DXd are antibody-drug conjugates (ADCs) that induce immunogenic cell death and bystander killing, enhancing antitumor immunity beyond target-specific cytotoxicity. These findings highlight novel mechanisms that can overcome antigen heterogeneity and suggest opportunities for improving ADC design and therapeutic synergy through informed combination with immunotherapies.
Oliver Kepp, Guido Guido Kroemer (2025). Immunogenic cell death and bystander killing: expanding the therapeutic potential of modern antibody-drug conjugates. , 14(1), DOI: https://doi.org/10.1080/2162402x.2025.2533488.
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Type
Article
Year
2025
Authors
2
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1080/2162402x.2025.2533488
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