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Get Free AccessSirtuins are deacetylase proteins that regulate transcription, genome maintenance, longevity, and metabolism. Eight compounds were identified as a novel class of sirtuin inhibitors, with 5, 7, and 9 being the most effective as SIRT1-selective inhibitors. In U937 cells 5 induced apoptosis and displayed antiproliferative effects in Raji, DLD1, and HeLa cancer cells, suggesting potential utility in cancer treatment.
Dante Rotili, Domenico Tarantino, Vincenzo Carafa, Ester Lara, Sarah Meade, Giorgia Botta, Angela Nebbioso, Jörg Schemies, Manfred Jung, Aleksey Kazantsev, Manel Esteller, Mario F. Fraga, Lucia Altucci, Antonello Mai (2010). Identification of Tri‐ and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors. , 5(5), DOI: https://doi.org/10.1002/cmdc.201000030.
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Type
Article
Year
2010
Authors
14
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/cmdc.201000030
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