0 Datasets
0 Files
Get instant academic access to this publication’s datasets.
Yes. After verification, you can browse and download datasets at no cost. Some premium assets may require author approval.
Files are stored on encrypted storage. Access is restricted to verified users and all downloads are logged.
Yes, message the author after sign-up to request supplementary files or replication code.
Join 50,000+ researchers worldwide. Get instant access to peer-reviewed datasets, advanced analytics, and global collaboration tools.
✓ Immediate verification • ✓ Free institutional access • ✓ Global collaborationJoin our academic network to download verified datasets and collaborate with researchers worldwide.
Get Free AccessSignificance The histone 3 lysine 9 demethylase Increase in BONSAI Methylation 1 (IBM1) is critical for preventing CHG (H=A, T, or C) methylation in plant genes. We found that the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) controls genome CHG methylation and transgene silencing by regulating alternative polyadenylation of IBM1 . EDM2 contains a composite plant homeo domain that simultaneously recognizes both repressive and active histone marks, allowing it to associate specifically with the intronic heterochromatin of IBM1 and other plant genes so that it may affect polyadenylation by methylating the RNA through an N6-adenine methyltransferase-like activity. This work significantly advances our understanding of the regulation of DNA methylome and mechanisms of antisilencing and alternative polyadenylation of intronic heterochromatin-containing genes.
Mingguang Lei, Honggui La, Kun Lu, Pengcheng Wang, Daisuke Miki, Zhizhong Ren, Cheng‐Guo Duan, Xingang Wang, Kai Tang, Liang Zeng, Lan Yang, Heng Zhang, Wen‐Feng Nie, Pan Liu, Jianping Zhou, Renyi Liu, Yingli Zhong, Dong Liu, Jian Kang Zhu (2013). <i>Arabidopsis</i> EDM2 promotes <i>IBM1</i> distal polyadenylation and regulates genome DNA methylation patterns. , 111(1), DOI: https://doi.org/10.1073/pnas.1320106110.
Datasets shared by verified academics with rich metadata and previews.
Authors choose access levels; downloads are logged for transparency.
Students and faculty get instant access after verification.
Type
Article
Year
2013
Authors
19
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1073/pnas.1320106110
Access datasets from 50,000+ researchers worldwide with institutional verification.
Get Free Access
