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Get Free AccessAbstract A new phase of the COVID-19 pandemic has started as several SARS-CoV-2 variants are rapidly emerging globally, raising concerns for increased transmissibility. As animal models and traditional in vitro systems may fail to model key aspects of the SARS-CoV-2 replication cycle, representative in vitro systems to assess variants phenotypically are urgently needed. We found that the British variant (clade B.1.1.7), compared to an ancestral SARS-CoV-2 clade B virus, produced higher levels of infectious virus late in infection and had a higher replicative fitness in human airway, alveolar and intestinal organoid models. Our findings unveil human organoids as powerful tools to phenotype viral variants and suggest extended shedding as a correlate of fitness for SARS-CoV-2. One-Sentence Summary British SARS-CoV-2 variant (clade B.1.1.7) infects organoids for extended time and has a higher fitness in vitro .
Mart M. Lamers, Tim I. Breugem, Anna Z. Mykytyn, Yiquan Wang, Nathalie Gröen, Kèvin Knoops, Debby Schipper, Jelte van der Vaart, Charlotte D. Koopman, Jingshu Zhang, Douglas C. Wu, Petra B. van den Doel, Theo M. Bestebroer, Corine H. GeurtsvanKessel, Peter J. Peters, Mauro J. Muraro, Hans Clevers, Nicholas C. Wu, Bart L. Haagmans (2021). Human organoid systems reveal <i>in vitro</i> correlates of fitness for SARS-CoV-2 B.1.1.7. , DOI: https://doi.org/10.1101/2021.05.03.441080.
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Type
Preprint
Year
2021
Authors
19
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/2021.05.03.441080
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