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Get Free AccessLeukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes at 31, with five highlighting nucleotide metabolism as an important regulator of LTL. We report six genome-wide significant loci in or near SENP7, MOB1B, CARMIL1, PRRC2A, TERF2, and RFWD3, and our results support recently identified PARP1, POT1, ATM, and MPHOSPH6 loci. Phenome-wide analyses in >350,000 UK Biobank participants suggest that genetically shorter telomere length increases the risk of hypothyroidism and decreases the risk of thyroid cancer, lymphoma, and a range of proliferative conditions. Our results replicate previously reported associations with increased risk of coronary artery disease and lower risk for multiple cancer types. Our findings substantially expand current knowledge on genes that regulate LTL and their impact on human health and disease.
Chen Li, Svetlana Stoma, Luca A. Lotta, Sophie C. Warner, Eva Albrecht, Alessandra Allione, Pascal P. Arp, Linda Broer, Jessica L. Buxton, Alexessander Couto Alves, Joris Deelen, Iryna O. Fedko, Scott D. Gordon, Tao Jiang, Robert Karlsson, Nicola D. Kerrison, Taylor K. Loe, Massimo Mangino, Yuri Milaneschi, Benjamin Miraglio, Natalia Pervjakova, Alessia Russo, Ida Surakka, Ashley van der Spek, Josine E. Verhoeven, Najaf Amin, Marian Beekman, Alexandra I. F. Blakemore, Federico Canzian, Stephen E. Hamby, Jouke‐Jan Hottenga, Peter D. Jones, Jari Lahti, Reedik Mägi, Sarah E. Medland, Grant W. Montgomery, Dale R. Nyholt, Markus Perola, Kirsi H. Pietiläinen, Veikko Salomaa, Elina Sillanpää, H. Eka D. Suchiman, Alan B. Zonderman, Gonneke Willemsen, Antonio Agudo, Heiner Boeing, Dorret I. Boomsma, María‐Dolores Chirlaque, Guy Fagherazzi, Pietro Ferrari, Paul W. Franks, Christian Gieger, Johan G. Eriksson, Marc J. Gunter, Sara Hägg, Iiris Hovatta, Liher Imaz, Jaakko Kaprio, Rudolf Kaaks, Timothy J. Key, Vittorio Krogh, Nicholas G. Martin, Olle Melander, Andres Metspalu, Concha Moreno, N. Charlotte Onland‐Moret, Peter M. Nilsson, Ken K. Ong, Kim Overvad, Domenico Palli, Salvatore Panico, Nancy L. Pedersen, Brenda W.J.H. Penninx, J. Ramón Quirós, Paul M Ridker, Miguel Rodríguez‐Barranco, Robert A. Scott, Gianluca Severi, P. Eline Slagboom, Tim D. Spector, Anne Tjønneland, Antonia Trichopoulou, Rosario Tumino, André G. Uitterlinden, Yvonne T. van der Schouw, Cornelia M. van Duijn, Elisabete Weiderpass, Eros Lazzerini Denchi, Giuseppe Matullo, Adam S. Butterworth, John Danesh, Nilesh J. Samani, Nicholas J. Wareham, Christopher P. Nelson, Claudia Langenberg, Veryan Codd (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. , 106(3), DOI: https://doi.org/10.1016/j.ajhg.2020.02.006.
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Type
Article
Year
2020
Authors
96
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.ajhg.2020.02.006
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