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Get Free AccessChronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Biobank participants (N = 427,367, European descent) and the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (total N = 575,531 European descent). We identify 266 independent loci, of which 211 are not previously reported. Gene-set analysis highlighted 42 gene sets associated with CRP levels (p ≤ 3.2 ×10
Saredo Said, Raha Pazoki, Ville Karhunen, Urmo Võsa, Symen Ligthart, Barbara Bodinier, Fotios Koskeridis, Paul Welsh, Behrooz Z. Alizadeh, Daniel I. Chasman, Naveed Sattar, Marc Chadeau‐Hyam, Εvangelos Εvangelou, Paul M Ridker, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan (2022). Genetic analysis of over half a million people characterises C-reactive protein loci. , 13(1), DOI: https://doi.org/10.1038/s41467-022-29650-5.
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Type
Article
Year
2022
Authors
17
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1038/s41467-022-29650-5
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