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Get Free AccessPG. Cyp7a1 hepatic expression was induced in and .This was associated to a reduced ileal Fgf15 gene expression in both groups (relative mRNA levels: 0.38±0.1 in PG and 0.08±001 in CTM vs. 1.102±0.23 in CG, p<0.05).Of note, CTM ileal gene expression of Fgf15 was significantly lower than PG (p<0.05).Conclusions: We confirmed the occurrence of down-regulation of export and import biliary genes and an upregulation of hepatic Cyp7a1 gene expression during pregnancy in mice.Ileal down-regulation of FGF15 gene expression is likely contributory to the observed pregnancy-associated upregulation of Cyp7a1 gene expression in the liver.In a setting of decreased canalicular export, increased expression of Cyp7a1 may raise bile salt levels inside the hepatocyte and contribute to cholestasis during pregnancy.
Agustı́n González, Tomás Rybertt, Juan Pablo Arab, Margarita Pizarro, Nancy Solı́s, Marco Arrese, Feng Huang, Dan Wang, Pu Chen, Ping Yang, Ju Cao, Ping Zhang, Yutaka Midorikawa, Shogo Yamamoto, Hiroki R. Ueda, Kotaro Sonoda, Shingo Tsuji, Kenji Tatsuno, Tatsuhiro Shibata, Kyle R. Covington, David A. Wheeler, Tadatoshi Takayama, Hiroyuki Aburatani, Daniela Sia, Bojan Losic, Kate Revill, Ke Hao, Laia Cabellos, Zhongyang Zhang, Yujin Hoshida, Sasan Roayaie, Swan N. Thung, Myron Schwartz, Samuel Waxman, Vincenzo Mazza- Ferro, Eric E. Schadt, Josep M. Llovet, Ana Alondra Sobrevilla-Navarro, Ana Sandoval-Rodríguez, Jesus Gar- Cia-Banuelos, Luis Daniel Hernández‐Ortega, José Macías‐Barragán, Juan Armendáriz‐Borunda, Adriana Salazar Montes, Zoe Raglow, Chuanghong Wu, Yu Wan, Khaleel Jamil, Kuldeep Cheent, Michael A. Heneghan, Marco A. Purbhoo, Salim I. Khakoo (2013). Gene Expression and Therapy. Hepatology, 58(S1), pp. 396A-412A, DOI: 10.1002/hep.26842.
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Type
Article
Year
2013
Authors
52
Datasets
0
Total Files
0
Language
English
Journal
Hepatology
DOI
10.1002/hep.26842
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