FIGURE 3 from Single-cell Multiomics Analysis of Myelodysplastic Syndromes and Clinical Response to Hypomethylating Therapy

Clonal evolution of responder and nonresponder patients with MDS upon AZA treatment. A, Clonal phylogenies of patients #3 and #14 (responders) and #4 and #8 (nonresponders) at diagnosis. Dot size represents clone size. B, Fishplots of patients #3 and #14 (responders) and #4 and #8 (nonresponders), illustrating the clonal distribution at diagnosis and after AZA treatment. C, Proportion of mutant cells (left) and predominant mutant clone (right) in responder patients at diagnosis and after AZA treatment. Dx, diagnosis; Aza, after AZA treatment.