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Get Free AccessThe Enhancing Neuroimaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This ‘genotype-first’ approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.
Ida E. Sønderby, Christopher R. K. Ching, Sophia I. Thomopoulos, Dennis van der Meer, Julio E. Villalón‐Reina, Ingrid Agartz, Katrin Amunts, Celso Arango, Nicola J. Armstrong, Rosa Ayesa‐Arriola, Geor Bakker, Anne S. Bassett, Dorret I. Boomsma, Robin Bülow, Nancy J. Butcher, Vince D. Calhoun, Svenja Caspers, Eva WC Chow, Sven Cichon, Simone Ciufolini, Michael Craig, Benedicto Crespo‐Facorro, Adam Cunningham, Anders M. Dale, Paola Dazzan, Greig Ian de Zubicaray, Srdjan Djurovic, Joanne Doherty, Gary Donohoe, Bogdan Draganski, Courtney A.S. Durdle, Stefan Ehrlich, Beverly S. Emanuel, Thomas Espeseth, Simon E. Fisher, Tian Gan, David C. Glahn, Hans J. Grabe, Raquel E. Gur, Boris A. Gutman, Jan Haakvik, Asta K. Håberg, Laura A. Hansen, Ryota Hashimoto, Derrek P. Hibar, Avram J. Holmes, Jouke‐Jan Hottenga, Hilleke E. Hulshoff Pol, Maria Jalbrzikowski, Emma EM Knowles, Leila Kushan, David E.J. Linden, Astri J. Lundervold, Sandra Martin‐Brevet, Kenia Martínez, Karen A. Mather, Samuel R. Mathias, Donna M. McDonald‐McGinn, Allan F. McRae, Sarah E. Medland, Torgeir Moberget, Claudia Modenato, Jennifer Monereo Sánchez, Clara Moreau, Thomas W. Mühleisen, Tomáš Paus, Zdenka Pausová, C. Prieto, Anjanibhargavi Ragothaman, Céline S. Reinbold, Tiago Reis Marques, Gabriela M. Repetto, Alexandre Reymond, David R. Roalf, Borja Rodríguez‐Herreros, James Rucker, Perminder S. Sachdev, J. Eric Schmitt, Peter R. Schofield, Ana Isabel Silva, Hreinn Stefánsson, Dan Joseph Stein, Daqiang Sun, Christian K. Tamnes, Diana Tordesillas‐Gutiérrez, Magnús Ö. Úlfarsson, Ariana Vajdi, Dennis van ‘t Ent, Marianne van den Bree, Javier Vázquez-Bourgón, fidel Vila-Rodriguez, G. Bragi Walters, Wei Wen, Lars T. Westlye, Katharina Wittfeld, Elaine H. Zackai, Kāri Stefánsson, Sébastien Jacquemont, Paul M. Thompson, Carrie E. Bearden (2021). Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs. , DOI: https://doi.org/10.31234/osf.io/57erc.
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Type
Preprint
Year
2021
Authors
100
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.31234/osf.io/57erc
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