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Get Free AccessThe emergence and spread of resistance in Plasmodium falciparum malaria to artemisinin combination therapies in the Greater Mekong subregion poses a major threat to malaria control and elimination. The current study is part of a multi-country, open-label, randomised clinical trial (TRACII, 2015-18) evaluating the efficacy, safety, and tolerability of triple artemisinin combination therapies. A very high rate of treatment failure after treatment with dihydroartemisinin-piperaquine was observed in Thailand, Cambodia, and Vietnam. The immediate public health importance of our findings prompted us to report the efficacy data on dihydroartemisinin-piperaquine and its determinants ahead of the results of the overall trial, which will be published later this year.
Rob W. van der Pluijm, Mallika Imwong, Nguyen Hoang Chau, Nhu Thi Hoa, Thuy-Nhien Nguyen, Ngo Viet Thanh, Podjanee Jittamala, Borimas Hanboonkunupakarn, Kitipumi Chutasmit, Chalermpon Saelow, Ratchadaporn Runjarern, Weerayuth Kaewmok, Rupam Tripura, Thomas J. Peto, Yok Sovann, Seila Suon, Sokunthea Sreng, Sivanna Mao, Savuth Oun, Sovannary Yen, Chanaki Amaratunga, Dysoley Lek, Rekol Huy, Mehul Dhorda, Kesinee Chotivanich, Elizabeth A. Ashley, Mavuto Mukaka, Naomi Waithira, Phaik Yeong Cheah, Richard J. Maude, Roberto Amato, Richard D. Pearson, Sónia Gonçalves, Christopher G. Jacob, William L. Hamilton, Rick M. Fairhurst, Joel Tärning, Markus Winterberg, Dominic Kwiatkowski, Sasithon Pukrittayakamee, Tran Tinh Hien, Nicholas Day, Olivo Miotto, Sir Nicholas White, Arjen M. Dondorp (2019). Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study. The Lancet Infectious Diseases, 19(9), pp. 952-961, DOI: 10.1016/s1473-3099(19)30391-3.
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Type
Article
Year
2019
Authors
45
Datasets
0
Total Files
0
Language
English
Journal
The Lancet Infectious Diseases
DOI
10.1016/s1473-3099(19)30391-3
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