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Get Free AccessChronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation that is greater in patients with advanced disease. We asked whether there is a link between the severity of disease and the reduction in histone deacetylase (HDAC) activity in the peripheral lung tissue of patients with COPD of varying severity. HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages.
Kazuhiro Ito, Misako Ito, W. Mark Elliott, Borja G. Cosío, Gaetano Caramori, Onn Min Kon, Adam Barczyk, Shizu Hayashi, Ian M. Adcock, James C. Hogg, Peter J Barnes (2005). Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease. , 352(19), DOI: https://doi.org/10.1056/nejmoa041892.
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Type
Article
Year
2005
Authors
11
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1056/nejmoa041892
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