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Get Free AccessIL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 cell response. Recently IL-1R-related protein (IL-1Rrp) has been cloned as the receptor for IL-18. However, the functional role of IL-1Rrp is still controversial due to its low affinity to IL-18 as well as the possibility of the presence of another high-affinity binding receptor. In the present study, we have generated and characterized IL-1Rrp-deficient mice. The binding of murine rIL-18 was not detected in Th1-developing splenic CD4+ T cells isolated from IL-1Rrp-deficient mice. The activation of NF-kappa B or c-Jun N-terminal kinase were also not observed in the Th1 cells. NK cells from IL-1Rrp-deficient mice had defects in cytolytic activity and IFN-gamma production in response to IL-18. Th1 cell development was also impaired in IL-1Rrp-deficient mice. These data demonstrate that IL-1Rrp is a ligand-binding receptor that is essential for IL-18-mediated signaling events.
Katsuaki Hoshino, Hiroko Tsutsui, Taro Kawai, Kiyoshi Takeda, Kenji Nakanishi, Yoshifumi Takeda, Akira Shizuo (1999). Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor. The Journal of Immunology, 162(9), pp. 5041-5044, DOI: 10.4049/jimmunol.162.9.5041.
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Type
Article
Year
1999
Authors
7
Datasets
0
Total Files
0
Language
English
Journal
The Journal of Immunology
DOI
10.4049/jimmunol.162.9.5041
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