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Get Free AccessPhages and cancer immunity Gut bacteria are involved in the education of T cell immune responses, and the intestinal ecosystem influences anticancer immunity. Fluckiger et al. report microbial antigens that might cross-react with antigens associated with tumor cells. They found that a type of intestinal bacteria called enterococci harbor a bacteriophage that modulates immune responses. In mouse models, administration of enterococci containing the bacteriophage boosted T cell responses after treatment with chemotherapy or programmed cell death protein 1 (PD-1) blockade. In humans, the presence of the bacteriophage was associated with improved survival after PD-1 immunotherapy. A fraction of human T cells specific for naturally processed melanoma epitopes appeared to be able to recognize microbial peptides. This “molecular mimicry” may represent cross-reactivity between tumors and microbial antigens. Science , this issue p. 936
Aurélie Fluckiger, Romain Daillère, Mohamed Sassi, Barbara S. Sixt, Peng Liu, Friedemann Loos, Corentin Richard, Catherine Rabu, Maryam Tidjani Alou, Anne‐Gaëlle Goubet, Fabien Lemaître, Gladys Ferrere, Lisa Derosa, Connie P.M. Duong, Meriem Messaoudene, Andréanne Gagné, Philippe Joubert, Luisa De Sordi, Laurent Debarbieux, Sylvain Simon, Clara‐Maria Scarlata, Maha Ayyoub, Belinda Palermo, Francesco Facciolo, Romain Boidot, Richard Wheeler, Ivo G. Boneca, Zsófia Sztupinszki, Krisztián Papp, István Csabai, Edoardo Pasolli, Nicola Segata, Carlos López-Otı́n, Zoltán Szállási, Fabrice André, Valerio Iebba, Valentin Quiniou, David Klatzmann, Jacques Bou Khalil, S. Khelaifia, Didier Raoult, Laurence Albigès, Bernard Escudier, Alexander Eggermont, Fathia Mami‐Chouaib, Paola Nisticò, François Ghiringhelli, Bertrand Routy, Nathalie Labarrière, Vincent Cattoir, Guido Guido Kroemer, Laurence Zitvogel (2020). Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage. , 369(6506), DOI: https://doi.org/10.1126/science.aax0701.
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Type
Article
Year
2020
Authors
52
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1126/science.aax0701
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