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Get Free AccessPolycystic ovary syndrome (PCOS) is a complex multifactorial disorder with a substantial genetic component. However, the clinical manifestations of PCOS are heterogeneous with notable differences between lean and obese women, implying a different pathophysiology manifesting in differential body mass index (BMI). We performed a meta-analysis of genome-wide association study (GWAS) data from six well-characterised cohorts, using a case-control study design stratified by BMI, aiming to identify genetic variants associated with lean and overweight/obese PCOS subtypes.
Kharis Burns, Benjamin H. Mullin, Loes M E Moolhuijsen, Triin Laisk, Jaakko Tyrmi, Jinrui Cui, Ky’Era V. Actkins, Yvonne V. Louwers, Andres Metspalu, Lili Milani, Tõnu Esko, Mari Nelis, Georgi Hudjashov, Lea K. Davis, Frank Dudbridge, Ricardo Azziz, Mark O. Goodarzi, Hannele Laivuori, Reedik Mägi, Jenny A. Visser, Joop S.E. Laven, Scott G. Wilson, Tugce Karaderi, Michelle R. Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Richa Saxena, Andres Metspalu, Lili Milani, Tõnu Esko, Mari Nelis, Georgi Hudjashov, Margrit Urbanek, M. Geoffrey Hayes, Guðmar Þorleifsson, Juan Fernández‐Tajes, Anubha Mahajan, Timothy D. Spector, Barbara Obermayer‐Pietsch, André G. Uitterlinden, Verneri Anttila, Benjamin M. Neale, Paul M Ridker, Mark J. Daly, Bart C.J.M. Fauser, Irina Kowalska, Marianne Andersen, Ken K. Ong, Elisabet Stener‐Victorin, David A. Ehrmann, Richard S. Legro, Andres Salumets, Mark I. McCarthy, Laure Morin‐Papunen, Unnur Þorsteinsdóttir, Hreinn Stefánsson, Unnur Styrkársdóttir, John R. B. Perry, Andrea Dunaif, Steve Franks, Cecilia M. Lindgren, Corrine K. Welt, Felix R. Day, Bronwyn Stuckey (2024). Body mass index stratified meta-analysis of genome-wide association studies of polycystic ovary syndrome in women of European ancestry. , 25(1), DOI: https://doi.org/10.1186/s12864-024-09990-w.
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Type
Article
Year
2024
Authors
69
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1186/s12864-024-09990-w
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