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Get Free AccessAbiraterone is a standard treatment for men with castration-resistant prostate cancer (CRPC). We evaluated the antitumour activity of abiraterone following the synthetic oestrogen diethylstilboestrol (DES). Castration-resistant prostate cancer patients treated with abiraterone were identified. Demographics, response variables and survival data were recorded. Two-hundred and seventy-four patients received abiraterone, 114 (41.6%) after DES. Pre-chemotherapy abiraterone resulted in ⩾50% PSA declines in 35/41 (85.4%) DES-naïve and 20/27 (74.1%) DES-treated patients. Post-docetaxel abiraterone resulted in ⩾50% PSA declines in 40/113 (35.4%) DES-naïve and 23/81 (28.4%) DES-treated patients. Time to PSA progression was similar regardless of prior DES. Abiraterone has important antitumour activity in men with CRPC even after DES exposure.
Aurelius Omlin, Carmel Pezaro, S. Zaidi, David Lorente, Deborah Mukherji, Diletta Bianchini, Roberta Ferraldeschi, Shahneen Sandhu, David P. Dearnaley, Chris Parker, Nicholas van As, Johann S. de Bono, Gerhardt Attard (2013). Antitumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer. , 109(5), DOI: https://doi.org/10.1038/bjc.2013.446.
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Type
Article
Year
2013
Authors
13
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1038/bjc.2013.446
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