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Get Free AccessAcute graft-versus-host disease (aGVHD) remains a major complication of allogeneic bone marrow transplantation, which is caused by donor T cells specific for host alloantigens. In a murine model, we found that donor T cells expressed a natural killer cell inhibitory receptor, CD94/NKG2A, during the course of aGVHD. Administration of an anti-NKG2A mAb markedly inhibited the expansion of donor T cells and ameliorated the aGVHD pathologies. These results suggested that the CD94/NKG2A inhibitory receptor expressed on host-reactive donor T cells can be a novel target for the amelioration of aGVHD.
Hiroki Kawamura, Hideo Yagita∥, Tetsuro Nisizawa, Nakako Izumi, Chikako Miyaji, Russell E. Vance, David H Raulet, Ko Okumura, Toru Abo (2005). Amelioration of acute graft-versus-host disease by NKG2A engagement on donor T cells. , 35(8), DOI: https://doi.org/10.1002/eji.200425933.
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Type
Article
Year
2005
Authors
9
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/eji.200425933
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