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Get Free AccessPhosphoinositide-specific phospholipase C (PLC) is a key enzyme in signal transduction. We have previously demonstrated that an antibody to an isozyme of PLC, PLC-delta, produced intense staining of neurofibrillary tangles in the brains of patients with Alzheimer's disease. In the present study, we investigated the protein level and activity of this enzyme in control and Alzheimer brains. Western blot analysis using a specific antibody for PLC-delta showed that the concentration of PLC-delta protein was significantly higher in the cytosolic fraction of Alzheimer disease cortical tissue than in control brains. The activity of PLC-delta, which hydrolyzes phosphatidylinositol, was also investigated, and we found that PLC-delta activity was not significantly different in the Alzheimer and control cytosolic fractions. These results indicate that the specific activity of PLC-delta is decreased in Alzheimer brains and suggest that inactivation of PLC-delta might be related to the pathophysiology of this disease.
Shun Shimohama, Sadaki Fujimoto, Hideyuki Matsushima, Tadafumi Takenawa, Takashi Taniguchi, George Perry, Peter J. Whitehouse, Jun Kimura (1995). Alteration of Phospholipase C‐δ Protein Level and Specific Activity in Alzheimer's Disease. , 64(6), DOI: https://doi.org/10.1046/j.1471-4159.1995.64062629.x.
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Type
Article
Year
1995
Authors
8
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1046/j.1471-4159.1995.64062629.x
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