Additional file 2: Figure S1. of Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

PlGF blockage induces vessel normalization. (A) Immunostaining for the endothelial marker endoglin (CD105). In HCC nodules, the capillary network is chaotically organized with tortuous vessels (indicated by red arrows) laying at large distances from each other. However, the capillaries in HCC after aPlGF treatment or in PlGFKO mice have a more normal appearance with regular pattern, size, and shape (indicated by green arrows). Black arrows and dashed lines indicate tumours. (B) Quantification of tortuous vessels per mm2; n = 5; *p