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Get Free AccessThis randomized, controlled trial shows that acetaminophen reduces kidney dysfunction and risk of developing acute kidney injury, particularly in severe malaria patients who present with high plasma hemoglobin, supporting the hypothesis that acetaminophen inhibits cell-free hemoglobin-mediated renal tubular oxidative damage.
Katherine Plewes, Hugh W. F. Kingston, Aniruddha Ghose, Thanaporn Wattanakul, Md Mahtab Uddin Hassan, Md Shafiul Haider, Prodip Kumar Dutta, Md Akhterul Islam, Shamsul Alam, Selim Md Jahangir, Abu Shahed Md Zahed, Md. Abdus Sattar, Mohiuddin Ahsanul Kabir Chowdhury, Michael Herdman, Stije J. Leopold, Haruhiko Ishioka, Kim A. Piera, Prakaykaew Charunwatthana, Kamolrat Silamut, Tsin Wen Yeo, Sue J. Lee, Mavuto Mukaka, Richard J. Maude, Gareth D. H. Turner, Md Abul Faiz, Joel Tärning, John A. Oates, Nicholas M. Anstey, Sir Nicholas White, Nicholas Day, Md Amir Hossain, L. Jackson Roberts, Arjen M. Dondorp (2018). Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial. Clinical Infectious Diseases, 67(7), pp. 991-999, DOI: 10.1093/cid/ciy213.
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Type
Article
Year
2018
Authors
33
Datasets
0
Total Files
0
Language
English
Journal
Clinical Infectious Diseases
DOI
10.1093/cid/ciy213
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