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Get Free AccessSignificance How heterochromatin affects RNA processing is unclear. The chromatin regulators ASI1 and EDM2 function in regulating alternative polyadenylation at genes with intronic heterochromatin. We found that ASI1 and EDM2 are associated in planta through interactions with a putative RNA-binding protein, AIPP1. Protein interaction assays suggest that the RNA Pol II C-terminal domain phosphatase CPL2 and two other proteins (AIPP2 and AIPP3) are associated with the ASI1-AIPP1-EDM2 complex. Like ASI1 and EDM2, AIPP1 also functions in promoting the expression of heterochromatin-containing genes. However, the function of CPL2, AIPP2, and AIPP3 is antagonistic to that of ASI1, EDM2, and AIPP1. Our discovery of the ASI1-AIPP1-EDM2 complex and associated proteins is important for understanding how heterochromatin regulates RNA processing.
Cheng‐Guo Duan, Xingang Wang, Lingrui Zhang, Xiansong Xiong, Zhengjing Zhang, Kai Tang, Pan Li, Chuan‐Chih Hsu, Huawei Xu, W. Andy Tao, Heng Zhang, Jian Kang Zhu (2017). A protein complex regulates RNA processing of intronic heterochromatin-containing genes in <i>Arabidopsis</i>. , 114(35), DOI: https://doi.org/10.1073/pnas.1710683114.
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Type
Article
Year
2017
Authors
12
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1073/pnas.1710683114
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