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Get Free AccessRNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed DNA Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis . Both RNA polymerase II (Pol II)- and Pol V-dependent transcripts are affected in the rdm4 mutant. RDM4 encodes a novel protein that is conserved from yeast to humans and interacts with Pol II and Pol V in plants. Our results suggest that RDM4 functions in epigenetic regulation and plant development by serving as a transcriptional regulator for RNA Pol V and Pol II, respectively.
Xin‐Jian He, Y. Y. Hsu, Shihua Zhu, Hailiang Liu, Olga Pontes, Jianhua Zhu, Xinping Cui, Co-Shine Wang, Jian Kang Zhu (2009). A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development. , 23(23), DOI: https://doi.org/10.1101/gad.1851809.
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Type
Article
Year
2009
Authors
9
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1101/gad.1851809
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