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The last 5 uploaded publications
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik, Eva M. Pålsson‐McDermott, Anne F. McGettrick, Gautam Goel, Christian Frezza, Nicholas J. Bernard, Beth Kelly, Niamh H. Foley, Liang Zheng, Agnès Gardet, Zhen Tong, S. S. Jany, Sinéad C. Corr, Moritz Haneklaus, Brian E. Caffrey, Kerry A. Pierce, Sarah R. Walmsley, Federico C. Beasley, Eoin P. Cummins, Victor Nizet, Moira K. B. Whyte, Cormac T. Taylor, Hening Lin, Seth L. Masters, Eyal Gottlieb, Vincent P. Kelly, Clary B. Clish, Philip E. Auron, Ramnik J. Xavier, Luke O'neill (2013). Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature, 496(7444), pp. 238-242, DOI: 10.1038/nature11986.
Article285 days agoOpsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists
Martin A. Bewley, Richard C. Budd, Eilíse M. Ryan, Joby Cole, Paul Collini, Jennifer L. Marshall, Umme Kolsum, Gussie Beech, Richard D. Emes, Irina Tcherniaeva, Guy A. M. Berbers, Sarah R. Walmsley, Gavin C. Donaldson, Jadwiga A. Wedzicha, Iain Kilty, William L. Rumsey, Yolanda Sánchez, Christopher E. Brightling, Louise Donnelly, Peter J Barnes, Dave Singh, Moira K. B. Whyte, David H. Dockrell (2018). Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists. , 198(6), DOI: https://doi.org/10.1164/rccm.201705-0903oc.
Article171 days agoLoss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis
Judit Kiss, Martin Mollenhauer, Sarah R. Walmsley, Johanna Kirchberg, Praveen Radhakrishnan, Thomas Niemietz, Johanna Dudda, Gunnar Steinert, Moira K. B. Whyte, Peter Carmeliet, Massimiliano Mazzone, Jürgen Weitz, Martin Schneider (2012). Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis. , 189(4), DOI: https://doi.org/10.4049/jimmunol.1103471.
Article74 days agoMutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression
Robert N. Jones, Kate E. McDonald, Joseph Willson, Bart Ghesquière, David Sammut, Eleni Daniel, A.J. Harris, Amy Lewis, A. A. Roger Thompson, Rebecca Dickinson, Tracie Plant, Fiona Murphy, Pranvera Sadiku, Brian Keevil, Peter Carmeliet, Moira K. B. Whyte, John Newell‐Price, Sarah R. Walmsley (2016). Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression. , 127(21), DOI: https://doi.org/10.1182/blood-2016-02-696922.
Letter74 days agoNRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease
Eilíse M. Ryan, Pranvera Sadiku, Patrícia Coelho, Emily Watts, Ailiang Zhang, Andrew J.M. Howden, Manuel A. Sánchez-García, Martin A. Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquière, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex von Kriegsheim, Yolanda Sánchez, William L. Rumsey, James F. Callahan, George Cooper, Nick Parkinson, J. Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley (2023). NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease. , 207(8), DOI: https://doi.org/10.1164/rccm.202203-0482oc.
Article74 days ago