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The last 5 uploaded publications
Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography
Albert H. Chan, Won‐Gil Lee, Krasimir A. Spasov, José A. Cisneros, Shalley N. Kudalkar, Zaritza O. Petrova, Amanda B. Buckingham, Karen S. Anderson, William L. Jorgensen (2017). Covalent inhibitors for eradication of drug-resistant HIV-1 reverse transcriptase: From design to protein crystallography. Proceedings of the National Academy of Sciences, 114(36), pp. 9725-9730, DOI: 10.1073/pnas.1711463114.
Article361 days agoPicomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers
Won‐Gil Lee, Kathleen M. Frey, Ricardo Gallardo‐Macias, Krasimir A. Spasov, Mariela Bollini, Karen S. Anderson, William L. Jorgensen (2014). Picomolar Inhibitors of HIV-1 Reverse Transcriptase: Design and Crystallography of Naphthyl Phenyl Ethers. ACS Medicinal Chemistry Letters, 5(11), pp. 1259-1262, DOI: 10.1021/ml5003713.
Article361 days agoFrom in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection
Shalley N. Kudalkar, Jagadish Beloor, Elias Quijano, Krasimir A. Spasov, Won‐Gil Lee, José A. Cisneros, W. Mark Saltzman, Priti Kumar, William L. Jorgensen, Karen S. Anderson (2017). From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection. Proceedings of the National Academy of Sciences, 115(4), DOI: 10.1073/pnas.1717932115.
Article361 days agoDesign, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents
Won‐Gil Lee, Albert H. Chan, Krasimir A. Spasov, Karen S. Anderson, William L. Jorgensen (2016). Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. ACS Medicinal Chemistry Letters, 7(12), pp. 1156-1160, DOI: 10.1021/acsmedchemlett.6b00390.
Article361 days agoStructural investigation of <scp>2‐naphthyl</scp> phenyl ether inhibitors bound to <scp>WT</scp> and <scp>Y181C</scp> reverse transcriptase highlights key features of the <scp>NNRTI</scp> binding site
Vincent N. Duong, Joseph A. Ippolito, Albert H. Chan, Won‐Gil Lee, Krasimir A. Spasov, William L. Jorgensen, Karen S. Anderson (2020). Structural investigation of <scp>2‐naphthyl</scp> phenyl ether inhibitors bound to <scp>WT</scp> and <scp>Y181C</scp> reverse transcriptase highlights key features of the <scp>NNRTI</scp> binding site. Protein Science, 29(9), pp. 1902-1910, DOI: 10.1002/pro.3910.
Article361 days ago