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Get Free AccessThe emergence and spread of artemisinin resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria eliminations ambitions. To investigate the artemisinin resistance mechanism, transcriptome analysis was conducted of 577 P. falciparum isolates collected in the GMS between 2016-2018. A specific artemisinin resistance-associated transcriptional profile was identified that involves a broad but discrete set of biological functions related to proteotoxic stress, host cytoplasm remodeling and REDOX metabolism. The artemisinin resistance-associated transcriptional profile evolved from initial transcriptional responses of susceptible parasites to artemisinin. The genetic basis for this adapted response is likely to be complex. One sentence summary The transcriptional profile that characterize artemisinin resistant infections with malaria parasites Plasmodium falciparum originates in the initial transcriptional response to the drug.
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A. Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Thuy-Nhien Nguyen, Paul N. Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J. Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas Day, Sir Nicholas White, Arjen M. Dondorp, Zbynek Bozdech (2021). The mechanism of artemisinin resistance of <i>Plasmodium falciparum</i> malaria parasites originates in their initial transcriptional response. bioRxiv (Cold Spring Harbor Laboratory), DOI: 10.1101/2021.05.17.444396.
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Type
Preprint
Year
2021
Authors
31
Datasets
0
Total Files
0
Language
English
Journal
bioRxiv (Cold Spring Harbor Laboratory)
DOI
10.1101/2021.05.17.444396
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