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Get Free AccessAbstract Arsenic is a metalloid toxic to plants, animals and human beings. Small ubiquitin-like modifier (SUMO) conjugation is involved in many biological processes in plants. However, the role of SUMOylation in regulating plant arsenic response is still unclear. In this study, we found that dysfunction of SUMO E3 ligase SIZ1 improves arsenite resistance in Arabidopsis. Overexpression of the dominant-negative SUMO E2 variant resembled the arsenite-resistant phenotype of siz1 mutant, indicating that SUMOylation plays a negative role in plant arsenite detoxification. The siz1 mutant accumulated more glutathione (GSH) than the wild type under arsenite stress, and the arsenite-resistant phenotype of siz1 was depressed by inhibiting GSH biosynthesis. The transcript levels of the genes in the GSH biosynthetic pathway were increased in the siz1 mutant comparing with the wild type in response to arsenite treatment. Taken together, our findings revealed a novel function of SIZ1 in modulating plant arsenite response through regulating the GSH-dependent detoxification.
Jian Kang Zhu, Zhen Wang, Yechun Hong, Yunjuan Chen, Huazhong Shi, Xiangfeng Kong, Juanjuan Yao, Mingguang Lei (2022). SUMO E3 ligase SIZ1 negatively regulates arsenite resistance via depressing GSH biosynthesis in Arabidopsis. , 2(1), DOI: https://doi.org/10.1007/s44154-021-00029-8.
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Type
Article
Year
2022
Authors
8
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1007/s44154-021-00029-8
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