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Get Free AccessPrepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO3 entered the endocytic organelles of a live cell, the NaHCO3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO2 gas. The evolution of CO2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture).
Cherng‐Jyh Ke, Tzu‐Yuan Su, Hsin‐Lung Chen, Hao‐Li Liu, Wei‐Lun Chiang, Po‐Chun Chu, Younan Xia, Hsing‐Wen Sung (2011). Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments. , 50(35), DOI: https://doi.org/10.1002/anie.201102852.
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Type
Article
Year
2011
Authors
8
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1002/anie.201102852
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