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  5. Sex Difference in Risk of Second but Not of First Venous Thrombosis

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Article
English
2013

Sex Difference in Risk of Second but Not of First Venous Thrombosis

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English
2013
Circulation
Vol 129 (1)
DOI: 10.1161/circulationaha.113.004768

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Frits R. Rosendaal
Frits R. Rosendaal

Leiden University

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R.E.J. Roach
Willem M. Lijfering
Frits R. Rosendaal
+2 more

Abstract

Background— The risk of recurrent venous thrombosis is 2-fold higher in men than in women. In contrast, no such sex difference in the risk of first venous thrombosis has been reported. We hypothesized that, for a first event, a risk difference between the sexes is masked by female exposure to reproductive factors (oral contraception, pregnancy/puerperium, and postmenopausal hormone therapy). Methods and Results— From the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis (MEGA) study, a population-based case-control study on risk factors for venous thrombosis, 2915 patients with a first venous thrombosis and their partners as control subjects were included. Odds ratios and 95% confidence intervals for first venous thrombosis were assessed in men compared with women without reproductive risk factors by use of conditional logistic regression. Analyses were stratified in 10-year age categories to account for the variation in exposure to reproductive risk factors over different age groups and adjusted for body mass index and smoking. Overall, men had a 2.1-fold (95% confidence interval, 1.9–2.4) increased risk of first venous thrombosis compared with women without reproductive risk factors. Similar results were found when 10-year age categories were viewed separately. Adjustment for body mass index and smoking and exclusion of cancer patients did not materially affect the results. Conclusions— When female reproductive risk factors are taken into account, the risk of a first venous thrombosis is twice as high in men as in women. These findings are in line with previous studies on recurrent venous thrombosis and may have implications for future treatment and prevention strategies.

How to cite this publication

R.E.J. Roach, Willem M. Lijfering, Frits R. Rosendaal, Suzanne C. Cannegieter, Saskia le Cessie (2013). Sex Difference in Risk of Second but Not of First Venous Thrombosis. Circulation, 129(1), pp. 51-56, DOI: 10.1161/circulationaha.113.004768.

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Publication Details

Type

Article

Year

2013

Authors

5

Datasets

0

Total Files

0

Language

English

Journal

Circulation

DOI

10.1161/circulationaha.113.004768

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