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Get Free AccessThe aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic - specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate.
Tina Kauss, Karen Gaudin, Alexandra Gaubert, Boubakar Ba, Serena Tagliaferri, Fawaz Fawaz, J Fabre, Jean‐Michel Boiron, Xavier Lafarge, Sir Nicholas White, Piero Olliaro, Pascal Millet (2012). Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment. International Journal of Pharmaceutics, 436(1-2), pp. 624-630, DOI: 10.1016/j.ijpharm.2012.07.030.
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Type
Article
Year
2012
Authors
12
Datasets
0
Total Files
0
Language
English
Journal
International Journal of Pharmaceutics
DOI
10.1016/j.ijpharm.2012.07.030
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