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Get Free AccessObjectives The aim of this study was to assess acute regurgitation following transcatheter aortic valve replacement, comparing different implanted transcatheter heart valves. Background Regurgitation following transcatheter aortic valve replacement influences all-cause mortality. Thus far, no quantitative comparison of regurgitation among multiple commercially available transcatheter heart valves has been performed. Methods Aortograms from a multicenter cohort of consecutive 3,976 transcatheter aortic valve replacements were evaluated in this pooled analysis. A total of 2,258 (58.3%) were considered analyzable by an independent academic core laboratory using video densitometry. Results of quantitative regurgitation are shown as percentages. The valves evaluated were the ACURATE (n = 115), Centera (n = 11), CoreValve (n = 532), Direct Flow Medical (n = 21), Evolut PRO (n = 95), Evolut R (n = 295), Inovare (n = 4), Lotus (n = 546), Lotus Edge (n = 3), SAPIEN XT (n = 239), and SAPIEN 3 (n = 397). For the main analysis, only valves with more than 50 procedures (7 types) were used. Results The Lotus valve had the lowest mean regurgitation (3.5 ± 4.4%), followed by Evolut PRO (7.4 ± 6.5%), SAPIEN 3 (7.6 ± 7.1%), Evolut R (7.9 ± 7.4%), SAPIEN XT (8.8 ± 7.5%), ACURATE (9.6 ± 9.2%) and CoreValve (13.7 ± 10.7%) (analysis of variance p < 0.001). The only valves that statistically differed from all their counterparts were Lotus (as the lowest regurgitation) and CoreValve (the highest). The proportion of patients presenting with moderate or severe regurgitation followed the same ranking order: Lotus (2.2%), Evolut PRO (5.3%), SAPIEN 3 (8.3%), Evolut R (8.8%), SAPIEN XT (10.9%), ACURATE (11.3%), and CoreValve (30.1%) (chi-square p < 0.001). Conclusions In this pooled analysis stemming from daily clinical practice, the Lotus valve was shown to have the best immediate sealing. This analysis reflects the objective evaluation of regurgitation by an academic core laboratory (nonsponsored) in a real-world cohort of patients using a quantitative technique.
Rodrigo Modolo, Chun Chin Chang, Mohammad Abdelghani, Hideyuki Kawashima, Masafumi Ono, Hiroki Tateishi, Yosuke Miyazaki, Michele Pighi, Joanna J. Wykrzykowska, Robbert J. de Winter, Andreas Rück, Alaide Chieffo, Martijn S. van Mourik, Kyohei Yamaji, Gert Richardt, Fábio Sândoli de Brito, Pedro A. Lemos, Baravan Al‐Kassou, Nicolò Piazza, Didier Tchetchè, Jan-Malte Sinning, Mohamed Abdel‐Wahab, Osama Soliman, Lars Søndergaard, Darren Mylotte, Yoshinobu Onuma, Nicolas M. Van Mieghem, Patrick W. Serruys (2020). Quantitative Assessment of Acute Regurgitation Following TAVR. КАРДИОЛОГИЯ УЗБЕКИСТАНА, 13(11), pp. 1303-1311, DOI: 10.1016/j.jcin.2020.03.002.
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Type
Article
Year
2020
Authors
28
Datasets
0
Total Files
0
Language
English
Journal
КАРДИОЛОГИЯ УЗБЕКИСТАНА
DOI
10.1016/j.jcin.2020.03.002
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