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Get Free AccessMalignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.
Adrien Joseph, Pan Juncheng, Judith Michels, Guido Guido Kroemer, Maria Castedo (2021). Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers. , 10(1), DOI: https://doi.org/10.1080/2162402x.2021.1950954.
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Type
Article
Year
2021
Authors
5
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1080/2162402x.2021.1950954
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