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Get Free AccessSignificance In plants, several DNA methylation pathways help maintain DNA methylation patterns to ensure that transposons remain in a silenced state and cell-specific DNA methylation is preserved after cell division. Here, we demonstrate that loss of function of the chromatin remodeler DDM1 induces a pathway conversion from CMT2- to RdDM-dependency to ensure the maintenance of CHH methylation. In plants defective in both DDM1 and RdDM, there is strong reactivation of TEs and a burst of TE transposition. Thus, our work not only identifies a variant of the RdDM pathway, but also shows that DNA methylation maintenance at a given locus is an adaptable process, revealing the existence of a double-insurance mechanism for the regulation of DNA methylation to guarantee genome integrity.
Li He, Cheng Zhao, Qingzhu Zhang, Gaurav Zinta, Dong Wang, Rosa Lozano‐Durán, Jian Kang Zhu (2021). Pathway conversion enables a double-lock mechanism to maintain DNA methylation and genome stability. , 118(35), DOI: https://doi.org/10.1073/pnas.2107320118.
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Type
Article
Year
2021
Authors
7
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1073/pnas.2107320118
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