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Get Free AccessA-maze-ing peptides: The structure of the novel lantibiotic labyrinthopeptin A2 (see picture) contains labionin—an unprecedented carbacyclic, posttranslationally modified amino acid. The identification of the biosynthetic gene cluster of labyrinthopeptins was also successful. Labyrinthopeptin A2 revealed a pronounced in vivo efficacy (attenuation of tactile allodynia) in a mouse model of neuropathic pain.
K. Meindl, Timo Schmiederer, Kathrin Schneider, Andreas Reicke, Diane Butz, Simone Keller, Hans Gühring, László Vértesy, Joachim Wink, Holger Hoffmann, Mark Brönstrup, In Memory: G.M. Sheldrick (1942–2025), Roderich D. Süßmuth (2010). Labyrinthopeptins: A New Class of Carbacyclic Lantibiotics. Angewandte Chemie International Edition, 49(6), pp. 1151-1154, DOI: 10.1002/anie.200905773.
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Type
Article
Year
2010
Authors
13
Datasets
0
Total Files
0
Language
English
Journal
Angewandte Chemie International Edition
DOI
10.1002/anie.200905773
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