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Get Free AccessProgress in therapy for cryptococcal meningitis has been slow because of the lack of a suitable marker of treatment response. Previously, we demonstrated the statistical power of a novel endpoint, the rate of clearance of infection, based on serial quantitative cultures of cerebrospinal fluid, to differentiate the fungicidal activity of alternative antifungal drug regimens. We hypothesized that the rate of clearance of infection should also be a clinically meaningful endpoint.
Tihana Bicanic, Conrad Muzoora, Annemarie E. Brouwer, Graeme Meintjes, Nicky Longley, Kabanda Taseera, Kevin Rebe, Angela Loyse, Joseph N Jarvis, Linda‐Gail Bekker, Robin Wood, Direk Limmathurotsakul, Wirongrong Chierakul, Kasia Stepniewska, Sir Nicholas White, Shabbar Jaffar, Thomas S. Harrison (2009). Independent Association between Rate of Clearance of Infection and Clinical Outcome of HIV‐Associated Cryptococcal Meningitis: Analysis of a Combined Cohort of 262 Patients. Clinical Infectious Diseases, 49(5), pp. 702-709, DOI: 10.1086/604716.
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Type
Article
Year
2009
Authors
17
Datasets
0
Total Files
0
Language
English
Journal
Clinical Infectious Diseases
DOI
10.1086/604716
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