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Get Free AccessAt odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy.
Giulia Petroni, Aitziber Buqué, Laurence Zitvogel, Guido Guido Kroemer, Lorenzo Galluzzi (2020). Immunomodulation by targeted anticancer agents. , 39(3), DOI: https://doi.org/10.1016/j.ccell.2020.11.009.
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Type
Article
Year
2020
Authors
5
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1016/j.ccell.2020.11.009
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