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Get Free AccessHow dying tumor cells get noticed Besides killing tumor cells directly, some chemotherapies, such as anthracyclines, also activate the immune system to kill tumors. Vacchelli et al. discovered that in mice, anthracycline-induced antitumor immunity requires immune cells to express the protein formyl peptide receptor 1 (FPR1). Dendritic cells (DCs) near tumors expressed especially high amounts of FPR1. DCs normally capture fragments of dying tumor cells and use them to activate nearby T cells to kill tumors, but DCs lacking FPR1 failed to do this effectively. Individuals with breast or colon cancer expressing a variant of FPR1 and treated with anthracyclines showed poor metastasis-free and overall survival. Thus, FPR1 may affect anti-tumor immunity in people, too. Science , this issue p. 972
Erika Vacchelli, Yuting Ma, Elisa Elena Baracco, Antonella Sistigu, David Enot, Federico Pietrocola, Heng Yang, Sandy Adjemian, Kariman Chaba, Michaëla Semeraro, Michele Signore, Adele De Ninno, Valeria Lucarini, Francesca Peschiaroli, Luca Businaro, Annamaria Gerardino, Gwenola Manic, Thomas Ulas, Patrick Günther, Joachim L. Schultze, Oliver Kepp, Gautier Stoll, Céline Lefèbvre, Claire Mulot, Francesca Castoldi, Sylvie Rusakiewicz, Sylvain Ladoire, Lionel Apétoh, José Manuel Bravo‐San Pedro, Monica Lucattelli, Cécile Delarasse, Valérie Boige, Michel Ducreux, Suzette Delaloge, Christophe Borg, Fabrice André, Giovanna Schiavoni, Ilio Vitale, Pierre Laurent‐Puig, Fabrizio Mattei, Laurence Zitvogel, Guido Guido Kroemer (2015). Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. , 350(6263), DOI: https://doi.org/10.1126/science.aad0779.
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Type
Article
Year
2015
Authors
42
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1126/science.aad0779
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