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Get Free AccessGeneralised spike wave (GSW) discharges are the electroencephalographic (EEG) hallmark of absence seizures, clinically characterised by a transitory interruption of ongoing activities and impaired consciousness, occurring during states of reduced awareness. Several theories have been proposed to explain the pathophysiology of GSW discharges and the role of thalamus and cortex as generators. In this work we extend the existing theories by hypothesizing a role for the precuneus, a brain region neglected in previous works on GSW generation but already known to be linked to consciousness and awareness. We analysed fMRI data using dynamic causal modelling (DCM) to investigate the effective connectivity between precuneus, thalamus and prefrontal cortex in patients with GSW discharges.
Anna Elisabetta Vaudano, Helmut Laufs, Stefan J. Kiebel, David W. Carmichael, Khalid Hamandi, Maxime Guye, John S. Thornton, Roman Rodionov, Karl Friston, John S. Duncan, Louis Lemieux (2009). Causal Hierarchy within the Thalamo-Cortical Network in Spike and Wave Discharges. , 4(8), DOI: https://doi.org/10.1371/journal.pone.0006475.
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Type
Article
Year
2009
Authors
11
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.1371/journal.pone.0006475
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