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Get Free AccessAmodiaquine is a 4-aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but the relationship of these changes to drug concentrations is not well characterized.
Xin Hui S Chan, Palang Chotsiri, Rebecca A. Capel, James Pike, Borimas Hanboonkunupakarn, Sue J. Lee, Maryam Hanafiah, Yan Naung Win, Maegan A. Cremer, Jean‐René Kiechel, Bernhards Ogutu, Walter Taylor, Rebecca A.B. Burton, Joel Tärning, Sir Nicholas White (2022). Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies. British Journal of Clinical Pharmacology, 89(3), pp. 1176-1186, DOI: 10.1111/bcp.15569.
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Type
Article
Year
2022
Authors
15
Datasets
0
Total Files
0
Language
English
Journal
British Journal of Clinical Pharmacology
DOI
10.1111/bcp.15569
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