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  5. Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies

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Article
English
2022

Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies

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0 Files

English
2022
British Journal of Clinical Pharmacology
Vol 89 (3)
DOI: 10.1111/bcp.15569

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Sir Nicholas White
Sir Nicholas White

University Of Cambridge

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Xin Hui S Chan
Palang Chotsiri
Rebecca A. Capel
+12 more

Abstract

Amodiaquine is a 4-aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metabolite desethylamodiaquine. Amodiaquine can cause bradycardia, hypotension, and electrocardiograph QT interval prolongation, but the relationship of these changes to drug concentrations is not well characterized.

How to cite this publication

Xin Hui S Chan, Palang Chotsiri, Rebecca A. Capel, James Pike, Borimas Hanboonkunupakarn, Sue J. Lee, Maryam Hanafiah, Yan Naung Win, Maegan A. Cremer, Jean‐René Kiechel, Bernhards Ogutu, Walter Taylor, Rebecca A.B. Burton, Joel Tärning, Sir Nicholas White (2022). Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies. British Journal of Clinical Pharmacology, 89(3), pp. 1176-1186, DOI: 10.1111/bcp.15569.

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Publication Details

Type

Article

Year

2022

Authors

15

Datasets

0

Total Files

0

Language

English

Journal

British Journal of Clinical Pharmacology

DOI

10.1111/bcp.15569

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