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Get Free AccessAutophagy extends lifespan via vacuolar acidification – In view of the fact that macroautophagy (hereafter described as autophagy) constitutes (one of) the major anti-aging pathway(s), we evaluated the hypothesis that methionine could act as an important and potent autophagic regulator. Indeed, we discovered that MetR induces a rapid and long-lasting increase in autophagic flux. Importantly, deletions of genes that are essential for (...)
Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona‐Gutiérrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Ivan Hajnal, Alice G. Sorgo, Tobias Eisenberg, Sabrina Buettner, Guillermo Mariño, Rafał Kozieł, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Pidder Jansen‐Dürr, Kai-Uwe Froehlich, Guido Guido Kroemer, Frank Madeo (2014). Autophagy extends lifespan via vacuolar acidification. , 1(5), DOI: https://doi.org/10.15698/mic2014.05.147.
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Type
Letter
Year
2014
Authors
22
Datasets
0
Total Files
0
Language
en
DOI
https://doi.org/10.15698/mic2014.05.147
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