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Self-healing hydrogels as injectable implants: Advances in translational wound healing

Abstract

Self-healing hydrogels' remarkable dependability and enduring stability have made them stand out as extremely promising soft materials for tissue engineering. The mechanism behind their self-healing capabilities relies on reversible physical or chemical interactions that result in cross-linking. Researchers are designing and developing self-healing hydrogels with captivating characteristics such as impressive biocompatibility, responsiveness, conductivity, and mechanical and antibacterial properties. These desirable characteristics are tailored to meet the specific requirements of practical applications. This comprehensive review focuses on the latest progress in making hydrogels with self-healing properties and employing them to help heal wounds. Synthesis strategies may occasionally employ a combination of reversible physical or chemical cross-linking processes. Furthermore, the diverse therapies of these hydrogels encompass adhesive properties, wound-healing capabilities, drug-delivery systems, and more. Lastly, this review addresses self-healing hydrogels and tackles and explores future development prospects. The potential for these materials to revolutionize the area of tissue engineering is discussed, emphasizing their capability to overcome obstacles and pave the way for enhanced medical treatments.

article Review

date_range 2024

language English

link Link of the paper

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Khattak Saadullah

Ullah Ihsan

Xie Hailin

Tao Xu-Dong

Xu Hong

Shen Jianliang

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Featured Keywords

Wound healing

Self-healing hydrogel

Infected wound

Bio-medical applications

Injectable

Tissue engineering

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Assessment of reinforced concrete building damages following the Kahramanmaraş earthquakes in Malatya, Turkey (February 6, 2023)

Abstract

Earthquakes of magnitude Mw = 7.7 and Mw = 7.6 hit the city of Kahramanmaraş (Turkey) on 6 February 2023. These earthquakes caused serious damage in 11 provinces in Turkey resulting in over 50,000 deaths and huge economic losses with the collapse of thousands of buildings. Two consecutive devastating earthquakes have severely damaged the reinforced concrete building stock located in Malatya. There are many reasons reinforced concrete structures suffer damage under the influence of seismic loads. These reasons can be listed as material and section properties that do not comply with earthquake codes, workmanship defects, ground parameters that are not considered and design errors, as seen in field investigations after earthquakes in Turkey in the past. In this research, a field study was conducted on reinforced concrete buildings damaged after the earthquakes in Malatya province. The causes of structural damages in reinforced concrete buildings between 6–26 years of age were assessed in terms of design and material defects. The structural damages were mainly caused due to insufficient stirrups in structural members, short column, strong beam–weak column, failures of infill walls, soft story type collapse, poor concrete quality, and reinforcement corrosion. In addition to the field investigation, the spectrum relationships created using raw acceleration data obtained from DEMP (Disaster and Emergency Management Presidency) stations in Malatya province were compared with the design response spectra.

article Article

date_range 2024

language English

link Link of the paper

Collapsed buildings

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